Updated at 11:40 a.m. ET

Actress Roseanne Barr says she was "Ambien tweeting" at 2 in the morning when she posted a racist tweet about Valerie Jarrett, a former senior adviser in the Obama White House, that caused ABC to cancel her TV show.

The reboot of Barr's eponymous TV show was canceled Tuesday after one season. ABC Entertainment's president announced the network was pulling the plug after Barr tweeted that Jarrett, who now serves on several corporate boards and is a senior fellow at the University of Chicago Law School, is the product of the "muslim brotherhood & planet of the apes."

Barr said shortly before 10:30 a.m. Tuesday: "I apologize. I am now leaving Twitter." She later sent dozens of tweets in which she apologized and offered up a number of reasons for her offensive comment.

"It was 2 in the morning and I was ambien tweeting — it was memorial day too — I went 2 far & do not want it defended," Barr said in a tweet Tuesday night.

She also said she believed Jarrett was Saudi or Jewish or Persian, rather than black. But when she invoked the sleep aid, her critics pounced.

From Ragnorak Lobster, on Twitter:

"AMBIEN SIDE EFFECTS: Peddling bizarre conspiracy theories, voting for white nationalists, doing photo shoots while dressed as Hitler and tanking your career by calling black women apes. If your racism lasts longer than four hours, please see a doctor."

Ambien's manufacturer, Sanofi-Aventis, responded to the news on Wednesday, saying via Twitter, "While all pharmaceutical treatments have side effects, racism is not a known side effect of any Sanofi medication."

Listing Ambien's actual side effects on its website, the company's warnings and precautions for Ambien include a section on "Abnormal Thinking and Behavioral Changes" — saying the side effects can include a lack of inhibition.

Sanofi-Aventis also tells people to stop taking Ambien if they find themselves performing complex behaviors — like making phone calls or driving a car — without being fully awake.

"It can rarely be determined with certainty whether a particular instance of the abnormal behaviors listed above is drug induced, spontaneous in origin, or a result of an underlying psychiatric or physical disorder," the company says.

Later, Barr denied that she was putting the blame on Ambien, saying it was "just an explanation not an excuse."

On Wednesday morning, Barr replied to one critic on Twitter, "Yes, I have had odd ambien experiences on tweeting late at night-like many other ppl do. I BLAME MYSELF OK?"

President Trump has since chimed in on Twitter — not exactly defending Barr, but rather complaining about his own treatment. "Bob Iger of ABC called Valerie Jarrett to let her know that 'ABC does not tolerate comments like those' made by Roseanne Barr," he wrote. "Gee, he never called President Donald J. Trump to apologize for the HORRIBLE statements made and said about me on ABC. Maybe I just didn't get the call?"

It's not immediately clear what statements Trump was referring to.

With the Roseanne show canceled, others who were involved with the project weighed in on the star's comments — including Sara Gilbert, who had been executive producer on the reboot.

Gilbert said the remarks are "abhorrent and do not reflect the beliefs of our cast and crew or anyone associated with our show," adding that she is disappointed in her longtime friend and colleague.

In her initial response to that tweet, Barr said, "Wow! unreal."

But on Wednesday, she took a softer stance, coming to Gilbert's defense after one of her followers sent a critical tweet.

"No, I understand her position and why she said what she said," Barr said. She added that she forgives Gilbert, saying, "It just shocked me a bit, but I indeed [f*****] up."

In addition to her remark about Jarrett, Barr is also being criticized over her recent attacks on both Chelsea Clinton and billionaire George Soros, who is a prominent donor to Democratic campaigns. On Monday, Barr regurgitated a rumor that Clinton had married a nephew of Soros — a rumor that was popularized by actor and Trump supporter Scott Baio shortly before the 2016 presidential election.

Clinton replied to Barr early Tuesday, "Good morning Roseanne — my given middle name is Victoria. I imagine George Soros's nephews are lovely people. I'm just not married to one."

Barr apologized but then followed it up by repeating another conspiracy theory — that Soros and his father worked with Nazis during World War II (a rumor that has been debunked and that Soros denounced again yesterday).

On Wednesday morning, Barr also invoked President Trump. Barr said, "i feel bad for @POTUS-he goes thru this every single day."

In addition to the cancellation of her rebooted show, reruns of the original program, which ran for much of the 1990s, were pulled by Viacom.

Copyright 2018 NPR. To see more, visit http://www.npr.org/.

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